I'm thinking about purchasing Colonization, but I have a few questions first. My computer is not hooked up to the internet, will this cause a problem with the DRM? I'm concerned that when I install the program it will try to connect, be unable and not let me play the game. Is this something I should worry about? Any thoughts would be very helpful. Thanks.

The only copy-protection is disk based. So you only need the CD in the drive to play. No "EA" style DRM policies in place. :)