OK, I admit it. I bought Spore and have been playing it since it's release. I've done quite a lot in the game and am starting to get the itch to play Colonization. My question is, has anyone ran into problems installing Colonization (with SecureROM), onto a system that already has some SecureROM based game on it? Thanks.

No. I run Spore & Col on the same laptop no issues.