Would it help to apply a universal 4GB Patch to reduce Civ5 crashes?

I noticed in Civ5 games on Giant Maps that the game becomes unstable around industrial age, when reaching 2 - 2.3 GB memory usage. Would it help to apply a "universal 4 GB memory patch" which changes the respective flag in a x86-exe to support 4GB rather than 2GB virtual memory on 64-bit-system?

see for example http://www.ntcore.com/4gb_patch.php