the only problem with a 4 partmap of the galaxy is that we knowthat the game can only have 7 civlizations
True; to have 4 quadrants you'd need 4 separate maps (although you could use the barbarians as an 8th civ). The best I could come up with is a 3 "quadrant" map: Alpha (with most of the TNG civs), Delta (with Borg and Hirogen) plus Liquid Universe in Voyager (http://forums.civfanatics.com/downloads.php?do=file&id=11016); the Ferengi are part of the barb controlled star systems.
And yes, it'd be quite a lot of work.