Bibor
Doomsday Machine
By the time you have both a university and an observatory you're probably not going to have that many renaissance techs left. There's also the fairly strong argument that a tech now is better than a tech in 100 turns time, and another 150-200 turns after that, especially if you're slingshotting deep.
That's because you make the two most common mistakes that people do:
a) that there's an infinite number of turns
b) that there's an infinite number of available scientists
Lets say you need to research an average of 60 techs per game (depending on your victory conditions, of course). Also lets say the game lasts, on average, for 350 turns.
How many great scientists can you produce during the course of that game? Lets say 6.
Lets say you get your 1st Academy in the Classical era and you build a national college there:
5 *1,5 = 7.5 ; average tech cost 110 takes 15 turns to pay off.
You get the 2nd Academy at time you get your University in the Medieval era:
10 * 2.0 = 20 ; average tech cost around 400 takes 20 turns to pay off.
You get the next 3rd Academy early renaissance and you build an Observatory there:
15 *2,5 = 37,5 ; average tech cost 800 takes 21 turn to pay off.
You get the 4th Academy at late renaissance and you build a Public school there:
20 *3,0 = 60 ; average tech cost 1450 takes 24 turns to pay off.
You add a 5th Academy in the industrial era:
25 *3,0 = 75 ; average tech cost 2100 takes 28 turns to pay off.
You add your final 6th Academy in the modern era as well as a research lab:
30 *4,0 = 120 ; average tech cost is 3000 so it finally takes 25 turns to get the return profit out of it.
***
Total number of beakers needed to research 60 techs: 53225
Average number of possible beaker gains from bulbing: 7860
Real effect of bulbing: 14% of total science needed (excluding the last 14 techs).
If all research would be equal during those 350 turns, the research pace would need to be 152 per turn (152*350=53200). With an average benefit of Academies being around 60 per turn (most benefit comes in the last 100 turns) total research generated by Academies would be 21000. This city alone with science buildings and Academies would make up 40% of your total needed research.
How about that.
The only thing you need to do is to build your science city adjacent to a mountain and with lots of production.
EDIT: High empire-wide research lowers the effects of both bulbing and Academies.