Even in the history of Modern America, the Pueblo are more important. The Spanish crown had plans to settle the interior of the US. But the Pueblo revolt that destroyed the Spanish colony cost the Spaniards billions in today's money, destroyed confidence and was the most devastating defeat of a colonial empire ever at that time, and without the Pueblo the Apache, Comanche, and Sioux wouldn't exist as we know them. The scrapping of Spain's plans to settle eastward and northwards forced the Spaniards to consolidate in Mexico and California. Without the Pueblo, much more of the US would have spoke Spanish and could have changed the map for the next several hundred years
The Pueblo captured thousands of horses from the fleeing Spaniards or killed the Spaniards who rode them and then later traded them to the Apache, Comanche, and other interior tribes. Without the Pueblo, cavalry culture in the US would not exist.