First you shouldn't automate workers, never ever. Apart from the fact that you may want to prioritize different things, they use really silly rules for improving (for example if you are in a Golden Age they will build Trading Posts all over because they yield an extra gold), they don't change improvements, and if they also build roads without you ever wanting them they cost a lot of GPT.
A road to a CS for the Quest is worth it but you can micro it to save some of GPT: pre-build the road, and stop when there is one turn left. Build the first road tiles in the CS border, and then finish the final segments quickly since they require a single turn, thus minimizing the maintenance cost to a small amount of turns. Once the road is complete and the quest is completed you can delete the road tiles and save on GPT.
Sending trade route to city states is less optimal, but in some situations it is worth it: for a cs quest, if you need to send a safe external route and you expect war with neighbors, on lower difficulties when you don't want to give beakers to the opponent, and of course if you are Germany for the production bonus.