This issue has been brought up quite a few times now since 64-bit OS's have become the norm (I remember asking it myself). The answer is fortunately very simple. You must uninstall the game, and them re-install in a folder that is NOT a sub-folder of Program Files, Program Files (x86), or, I'd assume Windows (but, I don't think it's a good idea to install any game directly into the Windows folder; it might not even let you). You can create a new "games" folder or such to make it a sub-folder of, or just have you Civ2 folder as it's own folder right on the main harddrive directory (like I do), or put it on a jump drive (like another member of the Scenario League does). I'm not sure if it would work if you put it's folder in My Documents, but, the thing is, you must NOT install in Program Files or Program Files (X86). I fold that helps.