It's not possible to research a disabled tech. It's red in the Tech screen, and you cannot click it.
I found it is not possible to disable it, while it is being researched actively. But it was possible to do some research on the tech, then switch to another tech, then disable the former tech. So for the function to be foolproof, it should stop research on the tech (if it is being actively researched), and then disable it. Dunno how to do that though.
EDIT: The popResearch function can remove the tech from the research queue, and then it can be disabled. Another problem I found though is, that when I disable a tech, and go to Main Menu to start a new game, it is still disabled in the new game. That's odd to me, but I guess I can do some kind of tech cleanup (set the techs to their proper disable-mode) at gamestart. Or perhaps there's some other way to get around this problem, that you know of?