* "Craig Ferguson has the most remarkable guest role of the year: He is playing a talking part of Leela's body. We discover that Leela has a little more to her being a mutant than we knew about."
* "Chris Elliott is playing a very persnickety space probe that goes around censoring things that it thinks are indecent, and he finds nudity both interesting and offensive."
* "George Takai will be back." (no more info available)
* "[..] Al Gore will be rejoining us in our environmental-themed holiday episode [airing next season]. He will help explain the future versions of Christmas, Robanukah, and Kwanza, along with Coolio, a natural pairing"
* "Patton Oswalt will appear in next season, playing a character called Unattractive Giant Monster."
* "Katee Sackhoff is playing a visitor to Comic-Con who has a fetish for aliens. She threw herself into the role in an impressive fashion."
"I would be remiss if I didn't mention the first appearance by David X. Cohen, in the Comic-Con episode. "
"The heads of Matt Groening and David X. Cohen will appear on a panel of writers for the new show that Matt Groening has created in the Year 3010."