1. Have open borders with 14 civs: Pretty easy, you just have to travel all around the world. 2. 12 resources: I have no idea what resources are these, much less what cities should I found or conquer. 3. 15 colonies: Easy, but I need to know when to build them so my economy doesn't kill me. I should be at my peak around 1580 but I'm just starting to build my empire then: I have vassalized Peru and Mexico, conquered Cordoba and have a few cities in Africa and Brazil at most. I'd like an overall strategy but my questions are: What to research? What to build? Which cities and when? EDIT: SultanRedSnake has provided a pretty good guide below.