Depending on empire size (larger maps allows larger empires) global unhappiness and global unhealthiness may go out of control.
There is no way to reduce pollution with units (source of global unhealthiness)
As for crime criminals may spawn faster than police can catch them (source of global unhappiness)
Disease is effectively obsoleted with some techs in Nanotech or Transhuman era.
Can you upload save?
Yeah but after having carefully sold the crime inducing buildings and putting few police units in the city, the crime still shot up by +503 and education went down -11. Just atrocious, abandoning city and building a new would be much more reasonable but there are nice wonders in there so this is damn annoying. Map isn't even a big one.
Save attached.
There is no way to reduce pollution with units (source of global unhealthiness)
Sure there are, park rangers and such.
As for crime criminals may spawn faster than police can catch them (source of global unhappiness)
Yeah but the AI must be able to respond to this. By the way, there were no criminals in the city and still isn't.

production is not split, I think. The factory is one of the most important