As America (one of my favorite CIVs) on any map larger than small, and any difficulty lower than Immortal I will ALWAYS open with 2 scouts. (Unless my initial warrior gets a goody hut with gold, and there is a few CS's nearby, meaning I can get 140 gold before I would start building the second scout).
Also, with the half priced tiles, I will abuse the heck out of land purchases. If I see any benificial tiles (especialy 3 food[cow], 2food, hammer gold [salt]), I will buy and work that tile asap, even if border growth would have given it to me in a turn or two. 25 gold is worth a turn faster pop growth IMHO. I find (because of this 'strategy') In the early game I am shorter on gold than usual, and will prioritize guilds faster than usual.