This game was not fun and relaxing.
As promised in my first spoiler, I did indeed attack Fred right after 1AD but only took one city (or maybe two?) just beyond the chokepoint. As I recall I had too few units to continue, and he probably had a tech advantage on me too. The Ottomans, however, were quite backward, as I discovered once my borders expanded enough to reach them, and I took their northern city. Once again, however, I didn't really have the units to effectively push for more cities so I took him as a vassal. Fred was still rather imposing so I turned to Gilly, who was roughly at tech parity. He had a LOT of units in his city directly west of my domain, and I was very worried that any stack I moved toward it would get torn up before they could lay siege, so I DoW'd him but didn't move in any units, hoping he would impetuously move most of his stack toward ME so I could chew it up with cannon. After about three anxious turns where he did nothing, he finally took the bait. I steadily but slowly captured his cities, advancing by land because his naval forces were far superior to mine (destroyers vs not-destroyers, I think?). After taking all but one of his mainland cities he finally capitulated.
Then it was back to Fred, who had relatively few cities on the mainland. After he cap'd, I kept on toward the Americans, who had meanwhile taken the fairly puny Celts as vassals (and shared all their techs with them). Once I took them under my benevolent wing, I finally achieved tech parity with them by directing all my vassals' research. That left Pacal, though, who still had quite a tech lead on me. The UN had passed a "Can't build nukes" resolution awhile back, but America had (just after I attacked them) nuked..... a barb city. Well, OK then. I didn't know if Pacal had any nukes--an oversight I should have corrected, although I'd still have to attack him. With my now large army I confidently besieged his northermost city and took it the next turn, moving in my 40-something units to heal up before advancing. Then I saw the ICBM land outside the city. "Eh, it's not that bad, I have a superhealer there who can...." and then I saw the second nuke go off. All gone. Ooops. He dropped another nuke on my staging area (captured from the Americans) but fortunately only one.
At this point I was about 1.5% away from the land area requirement for Domination, but no land was available for settling anymore. There was one Mayan city on an island with German and Sumerian cities that I could eventually capture, and a couple barb island cities remarkably still in existence, so I started schlepping units over (by transports and via airport drops) to prepare to capture them, but before I was ready, a UN victory vote came up, which I gladly accepted. That double-tap nuking really knocked the wind out of me, and Pacal was well into his spaceship building by then. I'm pretty sure I could have won it the ol' bare-knuckle fightin' way, but I'm glad I didn't have to. Thanks for the game, DS. I think I'll have to recover for awhile before I start a new one.