Usually Toronto's skyline is seen from the south, looking north. Often the photo is taken from a boat or one of the Toronto islands.
Here's a photo looking in the exactly opposite direction from about 6km north of the Lake Ontario waterfront. A lot of the skyscrapers you can see here aren't visible from the water, although you
can see the CN tower, plus a couple tops of the financial district buildings usually seen from the water, and some of the condos you'd see from a boat too.
The street you see running north-south is Yonge street, famously Canada's longest street.
Worth highlighting is the large cluster of skyscrapers visible in the near distance. It is about 3.3km from the lake.
That is Yonge/Bloor, the intersection of the two busiest subway lines in Canada, aka Midtown Toronto.
but wait, if you go further north, you run into more worthy skyscraper clusters.
8km north of the lake is Uptown aka Yonge/Eglinton, a bustling and fun part of town. It is also the intersection of the Yonge subway line and the new crosstown Eglinton LRT line
Of course about 15km north of the lake you'll find North York city centre.. which isn't technically a city anymore, since it was absorbed into Toronto in the 1990s.. I used to live near here once, not very far away from one of those single family homes in the very bottom left corner
18km north of the lake is Yonge/Steeles. Steeles Avenue is the northern border of the city of Toronto. This new proposed cluster with 65 story reaching buildings will straddle the border and spill out into York Region.
Worth mentioning is that a newly approved extension of the Yonge subway line will extend a further 4.5km north from here, so if we are still keeping track, that would be about 22.5km north of the lake.
70km north of the lake and you get to the end of Yonge Street, here, facing south. What's funny is that there's "no exit" signs because there's a brief gap in Yonge street coming up for some reason.
(turn around to see what lies even further north)
Some people say Yonge street keeps going as Highway 11 and is actually 1,896km long. I have no idea if it's actually Canada's longest street by any accepted standard of what a street is, but famously that's what it just is.