I always run it. I also always build coal plants in around 75% of my cities, so I always have 100 years of sickness. My population takes a hit, but I swear it's worth it. Corporations are still profitable if you build it in your wall street city. I think one of the probably 20 times I've played Sushi wasn't profitable because I had "too much" of the resources, so I only spread it to my border cities.
I get ahead in the production game with factories and power plants, take a hit population wise, get environmentalism and then make a big population come back. I don't understand how other people don't have the sickness problem, or how they can resist factories and power plants. As an expansive leader it's not so bad. Anways, if any one is wondering, I get this sickness even if I have every or almost every health resource. Also, medicine comes signifiicantly before ecology. Maybe next time I'll go free market, environmentalism, build recycle stations, and then back to free market, but by that point the game will almost certainly be over so it will be a moot point.