I finished my first game. Was going to do TSL earth, but did seven seas instead, with Spain. Science victory, emperor difficulty. One of the easiest wins I've had in ages. Spain getting such good internal trade routes (if you start near a continental border) early is insanely overpowered, you can grow your cities to all have campuses so fast, and buy a lot of libraries. Plus, Missions come earlier now and make pretty good science tiles. Spain is probably not a top tier science civ now, but I would probably put them just under that. Which is a big surprise considering that at launch they were barely scientific at all!