There is always point in game, when you need to put city in some inhospitable place without fresh water in order to get key strategic or luxury resource. Before neighborhoods, these cities will have up to 4 or 5 housing (with granary). So how do you plan build order for those cities, considering that they will start growing slowly from 2-3 population? What are key buildings they need? Granary? Walls in case of borders? What is that one district you will put in them, to be slowly build for dozen or turns?