Otherwise, you can't keep up with science. But if you can get it, then suddenly all of your Sugupus are generating +5 commerce AND +5 science/turn (even more if you built your cities right and use Reyna). With guilds and Reyna, you can potentially get a Sugubu with +40 (!) science and commerce per turn. (+10 Sugubu with Reyna's bonus and double commerce bonus from guilds).