Anything else I need to give ?
No, that is sufficient information to get an idea about your system.
And it does seem that your system is quite well equipped to play CivCol.
However, CivCol (and also Civ4) generally and thus also most mods have performance problems.
Also, sometimes bad coding (division by 0, endless loops in AI logic, ...) causes heavy problems.
We (the modders) have realized that and are trying to consider / avoid or fix these issues.
But of course this only happens in new mods
(meaning still in development).
(And we are still not where we want to be ...
has already given you some really good pointers
The only other thing I would add:
Turn off virus scanner while playing.
Otherwise, there is almost nothing we can do about your problems with a mod that is not in development
(Sorry if this answer is not very satisfying ...