I played single player as the Inca on emperor and got a 2,000 culture limit victory from my capital in 1410 AD with a score of 2400.
The agricultural trait along with the maize bonus gave insane amounts of food. My biggest problem early on was popping out enough settlers/workers and managing growth and happiness improvements to avoid perpetual overpopulation/disorder. But, that's a problem I can learn to live with.
With a good base of production established, I turned my attention to the my friendly, unsuspecting, and numerically inferior neighbors to the North, the Moche. Refraining from destroying too many cities left the Moche enough production to produce a steady stream of units to be converted to enslaved workers by my Chasqui Scouts. Eventually, I finished off the Moche and then wiped out the Toltecs, who were in Central American between me and the Mayans. The Chasqui aren't overpowering on offense and are vulnerable to counter attack, but attacking with endless waves of Scouts produced several dozen enslaved workers. By ~1250, I had enough to sacrifice and reach the one city culture limit.
Overall, I found the scenario to be interesting and worker enslavement ability to be a hoot and a holler. Also, the kick ass Silent Hunters (5/3/2, stealth attack) force a real change in tactics, as offensive units with low defense need to be protected behind defensive units and saved for counter attack. In fact, defense becomes problematic with the Silent Hunters around, so I favor nonstop attack.
The downside was that the starting position of the Inca is so isolated from the Maya and Aztec that I never had a chance to interact with these civs until late in the game, when it was pretty much decided. Abusing the minor tribes wasn't challenging, and I also accidentally almost got a domination victory just trying to get through the Moche and Toltecs to get to the "real" opponents. I am usually challenged on emperor, but I found this scenario to be too easy.
I'm curious the Maya and Aztecs provides a more interesting starting position???