The game is still going to be that unique? Not that Mr.House isn't unique but I'm not sure if he is every unit and building unique.
Anyway I guess he could be comparable to New Reno in some aspects, I haven't played Fallout 2 but I've read a bit about it. With a few major exceptions. Mr.House DOES NOT take direct profits from any drugs. New Vegas's economy is pretty much entirely powered by tourism, which doesn't seem to make much sense in a post apocalyptic world. But when you note that your closest neighbor is a Sudo-New America with an ultra consumerist population Mr.House's economic set up actually makes sense, it is also one of the reasons that despite wanting to push the NCR out of the Mojave region he still wants to maintain some form of diplomatic relations with them.
Mr. House's plans for the future are incredibly humorous to me. In his dialogue he says that after he secures New Vegas and the Hoover Dam he plans using New Vegas economy to kick start the development of new technology. With a long term goal, about 100 years, of sending colony ships into space to colonize distant habitable worlds.
I mean I like the character and his ambition is one of his key character traits but that is a bit much. Although I am confident that eventually he could achieve that particular goal. He was the man responsible for preventing Las Vegas from being completely obliterated. There were ~77 nuclear warheads aimed at New Vegas, he was able to prevent all but around 4 of them from getting through.
The general organization of New Vegas is somewhat interesting. New Vegas is basically set up in a manner in which Mr. House is, obviously, the leader and takes a cut of all profits from the casinos and any other enterprises that happen in New Vegas. The 3 families control the 3 major casinos on the Strip and are pretty much allowed to do whatever they want as long as they do not directly challenge Mr. House's authority. People are only allowed into the strip if they posses a passport, I presume something issued by House to any of his "Employees", or if they posses a large amount of currency. Note that you don't have to pay to enter the strip simply posses enough money.
The military of New Vegas is somewhat confusing to me. In the beginning when Mr. House first "emerged", sent Securitrons, out of the Lucky 38 Las Vegas was in a state of Decay, not from nuclear fire, simply from the fall of society. He used his relatively small force of Securitrons to recruit three tribes, which would eventually become the 3 casino families, to join his fledgling City State. He had also attempted to recruit at least 2 other tribes in the area, the Great Khans and the Kings, but was denied. Eventually Mr.House's forces came into conflict with the Great Khans over territory in out New Vegas. Then the NCR forces showed up in the region. The Great Khans assumed that Mr.House would never give up his precious city and thus attacked the NCR in hopes that House would join in. Mr. House knew his small force of Securitron and reconditioned tribals couldn't stand up to NCR and thus signed a treaty ensuring New Vegas independence for a time.
By the time the game actually starts the 3 families no longer seem to be inclined to serve Mr.House as fighters, not that he would need them in that regard at this point. By the end of the game, if you go with Mr.House, his military consists of a large army of Securitrons mass produced before the Great War specifically for the purpose of serving Mr.House. One of the interesting things about the Securitrons is that Mr.House is in constant contact with all of them. He knows exactly where they are, what they are doing, and can even use one as an interface with which to talk with someone.