Refer to the Overview and read the page notes:
http://forums.civfanatics.com/resources/photokinetik.25428/
NOTES/KNOWN ISSUES
-In-game MSAA
*MUST* be set to off for ReShade to have access to game's depth buffer for depth of field effects.
-If the depth of field effect is too strong for you, you can use Num Pad 0 to toggle it on/off or select an included preset that doesn't have depth of field enabled.
-The UIMask does not work yet on 1440p displays.
-Those using Depth of Field will inevitably have some issues with the shader blurring the UI. I made a UI mask for the static UI (The UI that is always on the screen), however it only works IF you scale the UI to your resolution. Currently this is not an option for 1440p displays. ReShade doesn't have the ability in any version to ignore the UI. Thus I have done what I can.
If you prefer a DoF effect that doesn't use MOUSEFOCUS, open ReShade Assistant, navigate to shaders, settings and disable the mouse autofocus.
Or the Changelogs:
CHANGE LOGS
1.4 Change Log:
-Reverted back to 1.1 color palette values.
-Renabled Mouse Focus for Depth of Field.
-Decreased Depth of Field Shader itensity.
-Decreased Godray Shader intensity.
-Enabled Levels Shader.
-Disabled Tuning Palette Shader.
-Disabled Vignette Shader.
-Disabled Finesharp Shader.
-Decreased Ambient Light Shader intensity.