I played this scenario as Rome, a lot of fun, even fighting off Hannibal's elephants as they tried to come over the Alps! I built the wonders when I played this Scenario, although some micromanaging of the cities is required at the onset, in order to speed up the rate at which they were being built. The wonders that provide happiness are very helpful since you'll be in a virtual state of war throughout the entire scenario. If you can manage to build the Great Library, you can then stop researching techs and throw all of your gold at rushing barracks and military units to conquer Carthage!
Diplomacy is also a huge part of this game, keeping the rest of the world at war with each other and Carthage, allows you to lead Rome to gretaness...