There are other things to consider thought. Knowledge increases science to grab techs that might grant health by buildings or biowells or whathever. The extra spy might do the same by stealing random techs and mitigating the loss on science when -10%. The plus culture lets you leap into other virtue branches. Might facilitates getting science by means other than research, to keep expanding by military conquest, increasing affinity exp and reaching higher levels of intrigue to keep on stealing instead of building on your own. I believe the devs thought that those two virtues trees would care less about health and instead would compensate by other means. Althougt I still they are kinda underpowered. For example, knowledge is about growing tall, but instead of helping to go that way it forces you into it.