In general, I don't think anti-imperialism is a very interesting theme in a game about empire-building. I mean, it's cool seeing Lautaro swinging around Philip's saber and all, but from a gameplay standpoint he's a very boring leader attached to a pretty fun civ. Similarly, I feel like either Tupac Amaru is going to be a boring leader attached to a hopefully interesting civ (Inca usually are, anyway). My perspective may be colored as an American, but educationally I think it's more worthwhile to emphasize that indigenous people built glorious empires without the help of aliens, Atlanteans, or wandering Egyptians than it is to emphasize that they lost insurrections (the loss of which wars and insurrections, in North America at least, has been a long-standing selling point of the inevitable superiority of Euro-American civilization). So I get what BuchiTaton and Evie are saying about emphasizing that indigenous people still exist and are still being colonized...but I don't see a way to do that without defining them by their conflict with Euro-American civilization, which I see as equally negative. (In general, I don't want to see civilizations defined by their relationships to other civilizations--this is among the many reasons I was happy to see Carthage, the anti-Rome, retired in favor of Phoenicia. However, this becomes especially true when that relationship is a dominance/resistance or colonizer/colonized relationship.)