Lily_Lancer
Deity
I've just finished another game where there were no scientific CS's at all. (they were not conquered, there just weren't any) This was on a small map. I did manage to get a tech lead by building more campuses and commercial districts, and running internal trade routes while working specialist slots. I clobbered all my neighbors, then wiped out the only other civ with any culture for a culture victory while I was researching the last of the Mars project techs. I built my spaceport a lot earlier this time.
I should try that Aztecs GOTM. Is the non-DLC version okay?
If you build a district on a good tile, like 2 hammers and a food or 2 food and a hammer, do your specialists give the base tile yield? I tend to build districts on my worst tiles (desert, snow, tundra, etc) that aren't good for anything else except eventually neighborhoods.
For cities, since the influence of amenity, in fact not more citizens lead to better yields. The best pop for a city is 6 due to my calculation, so for each city, you just have to assign where these 6 citizens will be working, and improve those tiles, the yield of other tiles are useless and you can assign districts freely.