A couple years ago, I was approaching A.D. 1 with a very high science score. In the waning BC years, I was making 4 discoveries per turn. In the A.D. 1 harvest, I got none at all. I know that the research box is supposed to double in size, but I was expecting to get at least one. At the conclusion of the harvest (city check) phase, I was greeted with a rather disconcerting science advisor's display (see the Empty Research attachment). At the time, I just assumed I had hit a limit in the allowable technology. Thinking that it was basically all over, I quit playing the game. Seeing the Civ Quiz thread inspired me to look into this a little more. As it turns out, all I needed to do was save and reload the game. The research box was restored (Full Research attachment). My quest for the ultimate high score is back on again. Anyway, what I mean by the Millennium Effect is the complete failure to make a discovery even though I generated enough bulbs to completely fill the newly doubled research box - and the subsequent display of a blank research box.