Yea, I had a pretty big tech lead my last game as Ramses.(or whoever the egyptian dude is)
4 continents, I had mine completely, continents were like triangle shaped with the all of them pointing in the middle and all had their base at the maps edges (hard to explain

)
I had a strong navy, but I felt that my diplomatic situation was so piss poor, that frankly I wasn't confident entirely on invading anyone.
I did eventually invade or at least declare war on sitting bull, I tried to woo stalin and darius on my side that way, but It didn't work, they just abstained in the UN vote ( I tried to win by UN initially so I built it before Manhattan, with some nasty scheming in mind...)
So, no one voted for me, UN went down to the drain, at that point the other victory conditions (score was crossed out) were conquest, domination, cultural (hard to get unless youve planned on winning by it), some one else had built Apostolic Palace so not that either...
And space race...
It dawned on me that Saladin had built Apollo Program first and was building casings and . .. .. .. . like crazy. I had gone physics->flight >radio and stuff like that. I was just about finishing manhattan project, then I went straight for rocketry naturally.
So at that point, I had military advantages, tanks, bombers, fighters, carriers, BBs DDs and generally a good navy with subs being built to carry tactical nukes also
problem was that saladin was strongest in power rating I think, and he was the one building SS parts, i would have to knock him out and somehow hold out against probably like 3 other civs who would gang up on me like they did before...
so I figured out it would be kinda hard to get them space ship parts, if all their productive lands were reduced to nuclear wasteland
that indeed worked out, first a wave of 9 tacticals hit saladin's production and cottage cities (slowing his research, he had lots of cottages I guess running a cottage economy?)
Then I nuked the most populous cities with ICBMs. I had about 3 very good prod cities, heroic epic+ moai+ academy, ironworks+national epic+academy, and lastly there was a pretty good production city with academy and all the fancy factories that I had in the aforementioned two top production cities.
So nuke production was guaranteed, and with that also enemies' nuke/space ship program's failure in getting there before me.
I also nuked stalin for revenge a couple of times for backstabbing me and not voting for me, and I just nuked the Inca's best city so they wouldn't get the Internet finished before me xD