I think North America would be an ideal place for a less experienced HP (human player) who wants to be in a large world. When setting up the game, make sure to click on an option that allows you to select computer opponents. Also, do not randomize the starting locations of the players. Thereafter, make sure to select computer players in such a way that you are the only one in the Americas.
In this way, the HP will have the space and time to expand and develop without having to look over his shoulders too much until many many turns later. (Though he must be prepared for Barbarian raids from time to time.) The point of this exercise is to get used to the nuts 'n bolts of building a large empire. (Need to get comfy with the 'mechanical' aspect of the game before taking on complex military campaigns.)
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On the other hand, if the HP wants something tougher, choose a civ that starts in the Middle East. Then, select computer opponents so that they are not far away. (i.e., the Greeks, the Russians, the Mongols) Alternatively, play the Carthaginians, the English, the Vikings, or the Japanese. Then select opponents so that they impose bottlenecks to the HP's need to expand into continents. (i.e., the HP runs the Carthaginians, but his opponents include the Spanish, the Zulus, and the Babylonians.)