I'm a mac girl and played on my Mac for the first couple of years. It was always a bother. First mods would break when an update went in but would work for me because of the time lag between when PCs for the update and when macs got it. Then people updated their mods, and now they were broken for me with my un-updated game. Finally, I would get the update and all would be good.. for a little while. I swear I spent more time not being able to play the latest version with working mods then when I could. It was maddening.
That (plus work, so not just Civ6) I bought a PC. So now I have a mac, which I spend most of my time on, but I also have a PC, which I use to play Civ6, Aardwolf (a textbased game) and do work stuff on. Works for me!!
bottom line as far as the subject of this thread, I could run just about any mod, as long as it worked for whatever version I was able to play on my mac (which generally wasn't the most current version)