I like it - my 500AD empire is just small enough to fit in a screenshot!
Intending to go for the cow in this one, using early astronomy plus conquistadors to pillage all AI into the stone age as soon as I can get to them, so I can conquer them in the 2040s, but with a 'Plan B' to divert and go for space if the AI are too advanced to conquer once I get to astronomy.
Initial strategy was to beeline for literature to build the great library, with the intention then of beelining for optics. I didn't seriously expect alphabet on the way to give me any trading opportunities so wasn't at all surprised when it didn't.
Great Library worked very well - thanks to heading for pottery/writing very early, I completed that in 350 BC, one of the fastest I think I've ever managed it. Even better - it meant Madrid had an academy in 150BC! (Am I allowed to send a

to myself on civfanatics?)
I didn't do much exploring at first, beyond what was needed to fogbust, which I put a lot of resources into. On this level, I'm sure any AIs that are reachable will discover me soon enough.
My 2nd city went SE by the horses and fish. 3rd one, Seville, S by the pig and sugar and in one of those clicking-too-quickly scenarios went in the
wrong place 
, intended to go 1 tile W to pick up the hill and auto-clear an extra jungle. At time I didn't know the iron was on the hill, when much later iron working rolled in, I realized that misclick screwed up a lot more than I'd bargained for, badly messing up all my dotmapping of city sites around the area.
I hesitated with the copper/dye/gold location because, although I'd dotmapped several possible city layouts, the best long-terms ones put the gold/copper city further from the capital than I felt comfortable with, given that at this point great library was my priority and I was throwing everything possible into science. Unfortunately that meant that some time before I finished the great library (in Madrid), Bismarck took the copper/gold (and the iron, though at that stage I didn't know it) for himself.
Since I couldn't leave myself hemmed in with Bismarck in control of such a powerful site, that meant I couldn't beeline straight for optics after literature, I'd have to go for construction next and attack Bismarck with catapults. (I could've gone for iron working, which I'd have needed anyway for jungle clearance, but that was risky: If there was no iron then I'd need construction anyway, and the war with Bismarck would then be later and he'd be a lot more powerful).
So my catapults knocked Bismark out of the copper. I then quickly stopped the war because my focus on science meant I didn't have the capacity to pursue it much, and Bismarck didn't have any other cities I particularly wanted. I did though capture the Barbarian city of Sarmatian up North, and filled in another city to make sure that I kept all the ivory. That should mean Bismarck would be unable to build anything except archers and horses, so I could contain him at my leisure

. Unfortunately that rapid expansion tanked my economy, and as the screenshot shows, in 500AD I'm only just breaking even on 0% science. Which isn't exactly making best use of that academy… The problem is the city happiness cap, so with metal casting in, my immediate priority is forges and calendar to let my cities grow. Luckily those are on the way to optics anyway, just hope I can still get there in time…