Looks to me like we now have our desired empire borders, and the priority now is to get to mass media as fast as possible.
Civics
We certainly need to change civics as soon as the Hagia Sophia is complete, and obviously need to decide which civics to go for. I remain of the opinion that pacifism will get us there fastest. I'm not sure whether caste system is good yet (get more scientists, but can no longer poprush and there's a lot of towns still needing quite a bit of infrastructure). I think we're nearing the point where we have enough towns to justify swapping from Caste System to Free Speech.
Commerce
We need to get cities working as many commerce tiles as possible now. I think that means we can start chopping quite a few forests. I'd suggest leaving two towns that have a reasonable production ability for defence purposes - Beijing and Coppertownski look best for that. Everywhere else, I'd replace forests, workshops and watermills by cottages, and mines on hills by cottages (on grassland-hills) and windmills (on plains-hills), leaving just enough to make sure each city has a decent food bonus (>= +4 food surplus/turn if possible) and some production to supply infrastructure. The newly captured towns may need more production initially if they have more infrastructure yet to build. Or we can continue poprushing infrastructure, which means we can cottage even more
I'd probably put all cities on to max food as well unless there's anything urgent they need to build, or they're already working all cottageable tiles.
Specialists
Have a couple of cities running specialists - Athens looks best to me for that. Moscow too after we've changed to Free Speech. We should build the National Epic in one of them too asap. From now on we want to avoid having towns running just one or two specialists that aren't going to give us great people (so eg. take the scientist out of New Novgorod).
Military
We're above average in our military size so probably don't have too much to worry about. I guess we want to get a few longbows and maces defending cities, and keep a small supply of knights on both continents to act as a rapid reaction force if we do get attacked. It's very unlikely we'd be facing any sizeable stack, since Mao is the only one who can attack us overland and he now has only 4 cities, 2 of those useless tundra ones, so he's not going to be much of a threat at all. I certainly don't see any need to build up massive military right now (especially if we do go to pacifism so unit costs will be higher). We should get some galleons out there for sea defence, to replace the triremes. We can get by with less military too if we position the galleons and caravels to look out for any potential sea-borne invasion fleet too, so we have reasonable warning if the worst does happen. Lodestone City may need a few additional units since it's alone on Lodestone Isle.
Civics
We certainly need to change civics as soon as the Hagia Sophia is complete, and obviously need to decide which civics to go for. I remain of the opinion that pacifism will get us there fastest. I'm not sure whether caste system is good yet (get more scientists, but can no longer poprush and there's a lot of towns still needing quite a bit of infrastructure). I think we're nearing the point where we have enough towns to justify swapping from Caste System to Free Speech.
Commerce
We need to get cities working as many commerce tiles as possible now. I think that means we can start chopping quite a few forests. I'd suggest leaving two towns that have a reasonable production ability for defence purposes - Beijing and Coppertownski look best for that. Everywhere else, I'd replace forests, workshops and watermills by cottages, and mines on hills by cottages (on grassland-hills) and windmills (on plains-hills), leaving just enough to make sure each city has a decent food bonus (>= +4 food surplus/turn if possible) and some production to supply infrastructure. The newly captured towns may need more production initially if they have more infrastructure yet to build. Or we can continue poprushing infrastructure, which means we can cottage even more

I'd probably put all cities on to max food as well unless there's anything urgent they need to build, or they're already working all cottageable tiles.
Specialists
Have a couple of cities running specialists - Athens looks best to me for that. Moscow too after we've changed to Free Speech. We should build the National Epic in one of them too asap. From now on we want to avoid having towns running just one or two specialists that aren't going to give us great people (so eg. take the scientist out of New Novgorod).
Military
We're above average in our military size so probably don't have too much to worry about. I guess we want to get a few longbows and maces defending cities, and keep a small supply of knights on both continents to act as a rapid reaction force if we do get attacked. It's very unlikely we'd be facing any sizeable stack, since Mao is the only one who can attack us overland and he now has only 4 cities, 2 of those useless tundra ones, so he's not going to be much of a threat at all. I certainly don't see any need to build up massive military right now (especially if we do go to pacifism so unit costs will be higher). We should get some galleons out there for sea defence, to replace the triremes. We can get by with less military too if we position the galleons and caravels to look out for any potential sea-borne invasion fleet too, so we have reasonable warning if the worst does happen. Lodestone City may need a few additional units since it's alone on Lodestone Isle.