Early alchemists, such as Zosimos of Panopolis (c. AD 300), highlight the spiritual nature of the alchemical quest, symbolic of a religious regeneration of the human soul.[14] This approach continued in the Middle Ages, as metaphysical aspects, substances, physical states, and material processes were used as metaphors for spiritual entities, spiritual states, and, ultimately, transformation. In this sense, the literal meanings of 'Alchemical Formulas' were a blind, hiding their true spiritual philosophy. Practitioners and patrons such as Melchior Cibinensis and Pope Innocent VIII existed within the ranks of the church, while Martin Luther applauded alchemy for its consistency with Christian teachings.[