In my current game as Poland, I had a very similar quandary. My initial thought was to attack Byzantium. They had plopped their second city right on my capital's border, stealing the copper resource in the process. After a brief war with them earlier (I just stole a worker and was not ready to really fight), I had built my infrastructure up to where I was looking to take the land I felt was mine to begin with. But then England beat me to the Great Library and another wonder I am forgetting. They did not have longbows yet and London had both wonders. I squeezed Lodz next to London so I could get the Altitude Training from Mt Kilamanjaro in every unit produced there. Had a sweet view of London and its total lack of units....hmmm....way too tempting. Theodora was afraid of me, kept telling me how wise I was and then offered a DOF. Which I took, knowing that eventually, she would hate me regardless of what I did to ensure friendship, so make it count while it lasted. Attacked England. Took London and York. Left her with Hastings and Nottingham. After Theodora beat me to Borodbhur (sp), I vented my rage on her and took the offensive Adrianople and Constantinople. Also go tired of Ramesses wonder hoarding. So now Thebes is mine. I had planned to go for a culture win....not sure that would be the best route now or not. I do have a lot of wonders that were built for me...except Notre Dame. I was 1 turn away when someone on the other continent built it. Sorry, this doesn't seem to have much of a point, but I am sympathizing over the question on who to attack....