If you're concerned about your registry entries, go to Snapfiles.com and download three freeware programs.
1) Spybot S&D
2) Adaware
3) Hijackthis.
Run Spybot and Adaware. Make sure you read the information that comes with them. Adaware has a custom scan that does a better job than the standard scan. Run both twice, restarting the computer each time to clear memory. (They each have a different approach to finding the nasties.)
Run Hijackthis and save the log. Go to Spywareinfo.com and check out the forums.
There are a number of posters there who can review the log and tell you what to do. Do
not fiddle with the registry unless you know exactly what you are doing. These folks can help.
Something else to remember:
Whenever you are trying to remove viruses or spyware from XP or ME you must disable the System Restore function (directions and explanation
here).
Finally, whenever you do a cache cleaning, clear your browser history, empty the recycle bin and restart the computer. This garbage sits in memory sometimes.
Another good source for dealing with spyware and adware is
Merijn.org. There is a great deal of information available there as well as links to some very helpful sites.
It may seem like a long, involved process, but if you want to rid yourself of this junk, you need to take the time so you do it correctly.