I strongly suggest playing Assyria, especially if you are going for a domination victory. I did a few basic techs for luxuries and writing and started on a conquest spree (on emperor). Basically after that initial ones, I only worked on techs to improve my military and the rest I just stole from finding new people and killing them. This helped to offshot that science negative for going wide. The benefits from building libraries and their special unit weren't bad either for this tactic.