OK, beetle, but don't try to complicate it too much. Just concentrate on what matters most to the VC that YOU are pursuing.
If you're playing peaceful, just be aware that, aside from literally 4 or 5 of the 43 civs, most will DoW you if it suits them, regardless of how many bright green modifiers you have. There are some on these boards who will swear that 5+ green modifiers or going to -100 or whatever it is will keep you safe, but if your military is below average, and they need lebensraum (especially if they are expansionist, they will think about DoWing you). So build that military and be ready for it.
If you're playing to win by Domination, then personality-wise you only need to be aware that certain civs just WILL NOT DoW others, and therefore you cannot make them look bad, prior to denouncing them yourself. So try to kill these ones early as poss, so that the diplo hit will recover later.
Far more important for both peaceful AND warring games is knowing who can get completely out of control unless dealt with. So an unmolested Korea can win anywhere between 220 and 280. Better to send someone after them, or if playing peaceful with no bribes, go for a faster, riskier win yourself.
Many civs have the ability to go out of control culture-wise, but if your tourism is high enough, you will probably still overcome them before anyone else wins.
If you want to PM me with more specific strategy problems, feel free. I'm not the best player, but I can usually win most maps nowadays.