I think it really depends on the land where you settle, of how much food you can grab from it, one time I played a game as Babylon, searching for a SV, my starting place was really bad for food production, so in order to produce more science I needed to found a city that can grow more quickly, very close from my capital I had a 3x hex radius area that easily was 80% grassland, with some wheat and rivers, but without luxuries or other resources, So I took the risk and I found a city in the center of that area, risky move, but it worth it, 200 turns later that city was producing almost the same amount of science than the actual 8 academy powered Babylon from that game.
So what i'm saying is, if the map favors you with good clay, nice resources that are at hand from your starting location, you're not necessarily forced to have only 4 cities the whole game, if the cities can grow fast, and you can sustain the growth rate of your civ, you are not being as efficient as you may think with having only 4 cities and wasting all that good dirt.