Depends. If you're good at diplomacy, then larger maps are easier (you can play everyone near you off everyone else, providing a buffer, and ignore the far away civs). If you're bad/lazy at diplomacy, then it's harder, because you essentially have more competition. Also, you get more turns to position your military optimally for battles before they go obsolete, so "I need to take Civ X down" becomes much easier, while "I need to take out all capitals" becomes harder, since timed-pushes get out-teched before you're done with your conquest spree. You'll likely end up with a spaceship victory trying to go for domination.
Generally, for immortal (I haven't tried deity on huge), all victory conditions besides science are slightly harder (domination takes more time to capture all the capitals; diplomacy takes much more gold and esp spies to hold down city states; culture has you in a steeper battle for early/mid wonders for your 2nd/3rd cities).
Also, Tradition/Liberty is balanced on a Large map, favors Tradition on normal maps, but tips in favor of Liberty for huge maps, which makes wide-strategies easier/safer to set up on huge maps, which favor certain civ strategies (say, Arabia, Inca, Rome).