Going straight from vanilla to everything since then has a lot of considerations, riverside cities are no longer cash cows, economy is more based on trade routes, possibly religion, and trading posts. Religion is new, World Congress is new, Culture victory is completely different and tourism is new.
But one of the biggest considerations is that almost all of the war-machine civilizations came out in later expansions. Aside from Mongolia, the only civ from vanilla with high war tendencies and capabilities is China. But even China is more of a balanced civ than a war machine - paper makers are obviously an infrastructure boost, and extra GG's work equally well as a turtling tactic (having choke-points blocked off with series of citadels,) so even China isn't "all-in" on aggression bonuses. Assyria, Zulu, and the Huns, along with Mongolia, are the civs that have nearly every aspect of their bonuses weighted at "kill everything in sight." So especially at Prince level, I'd recommend choosing one of these civs, barbarians-masquerading-as-civilizations, and pursuing a culture victory. Even if you miss most of the key tactics in achieving a culture victory, you'll get plenty of tourism from stealing their great works, and remember that you don't need to achieve influential tourism status with civilizations that you've exterminated. As far as familiarizing yourself with the new game elements while still having a crazy-fun time, that's my vote: forget Carnivale, chateaus, wonders, WC proposals and internet, win tourism with battering rams, keshiks, artillery, nukes and XCOMs.