I go to the store only to buy groceries (to eat) and on occassion to peruse the fine females. Though when you pick up women at a grocery store they tend to have alot of baggage (like kids) so I go like once a month when absolutely necessary. I get my toothpaste, shampoo, soap, deaordorant and all other essential personal hygiene products when I go for food.
Far as clothes and everything else is concerned it's generally more economical (with gas prices as they are) and more convenient to buy online. Almost all the clothes I wear have to be bought from Big and Tall (I'm a freaking giant man) so I just do the majority of all other shopping online. It's just easier and I don't have to put up with screaming babies and snotty little kids.
On a side note you can buy groceries online now, but it is pretty expensive to do if you ask me.