First I would like to reiterate the comments about government. Get the HELL out of despotism when you can. Despotism has a
penalty to production and economy. Your early options will be Republic and Monarchy and, a little later, Feudalism. My tendency is to go to monarchy and then to communism in the endgame. The best type for you depends on your style but Republic seems to be the most popular.
Another thing is to manage your cities. This is what is meant when players talk of micromanagement. Make sure your cities are doing the best for you. You can assign specific tiles to be worked by the city's people. Also, you can appoint citizens as specialists, but entertainers (sometimes called clowns) are generally avoided. It's usually better to adjust the luxury slider than to make a bazillion entertainers.
Also, manage your wars, especially on the offensive. When attacking a city it is better to attack with several units in one turn that to send them one at a time. Either mix in some artillery-type units (not all artillery though), or send only fast units (I prefer the latter, but again, styles vary). Gather a good strong stack, send them into enemy turf, and just kick some booty.
Lastly, manage your trade, down to the last unit. Trade deals are negotiable; the AI will always leave room for some haggling. Your trade advisor will tell you how the trade partner will react to your counteroffer. Optimising trade will mean that you'll have more left over for yourself for further trading, or for the luxury and science. Resources = survival.
Do villages give anything worthwhile to humans or should I just turn them off?
If you mean barbarian villages, yes, they can provide. You may get a tech advance or some cash, or a friendly warrior joining your side. If you're behind in expansion you may get a settler. Not always, though--sometimes the barbs will attack, but the player gets an advantage (in the RNG) versus barbarians, so you'll rarely lose, especially with the huge bonus (800% IIRC) given at Chieftain level.