Open Tradition, fill left side of Honor, find a City State whipping boy, steal their luxury with a citadel and farm XP until I've got ranged logistics x5. Start early and upgrade, you'll soon have the city on 0HP and not even yielding 10XP per turn. Don't rush for cheap upgrades policies, though - you'll get the money from loot and pillage. CBs punch way over their weight, XBs are great but no need to beeline; fill Tradition and, if I'm not on Pangaea, jump into Patronage and crack on with Astronomy.
Build a max of one Settler, so forget Liberty; if you've moved at the start to settle a coastal mountainside river hill near your CS victim, don't even bother. Get NC ASAP, maybe boosting with Tradition, once the wars begin you'll be constantly burning cities and selling their buildings so NWs will take ages. Burn everything that's not a capital. Even if it's got Petra. Seriously. Even with CM and GGs flying out to grab extra luxes, happiness is going to be the main limit, so prioritise policies that help with that.
Don't worry too much about trade routes. There'll be too much open space for you to win whack-a-mole with barbarians, and a few captured workers can just keep repairing improvements around a city you razed to support your army upkeep in pillage cycles. If you've got decent Patronage, a caravan's worth burning for an Ally with luxes or UU.
If it goes to the late game, fill out Honor over opening Rationalism; easily staying happy is better than a research boost when you're not unhappy. Once ideology is available, get stuck in. Tend to prefer Order - Socialist Realism feels better than Fortified Borders, and boosts to hammers, beakers & GP production are more useful than military bonuses when you're already farming promotions.
If I've got the choice, try to capture a high faith (Stonehenge, Festivals, Stone Circles) capital for founding a religion, but don't bother with Piety. Pagodas aren't worth the hassle of annexing cities. Exception: getting Interfaith Dialogue, a good shot at Djenne, and opportunity for a missionary > holy city production line. But Papal Primacy is probably best - with Holy Warriors or Religious Community to make your hammers go farther. Pilgrimage is pretty cool when you've got a continent to yourself full of city states to convert.