Dancing Hoskuld
Deity
You won't get past the industrial age (my experience w/ 32-bit OS, 3GB switch, 4GB total RAM and a Huge Map with 8 remaining Civs). Once everyone sports an airforce (with all those unit animations), the MAFs will get you. I'll start another game now with a 64-bit OS and 8GB RAM and see how far I'll get. However, I'm a bit pessimistic. Even though BtS is apparently IMAGE_FILE_LARGE_ADDRESS_AWARE, that's still just 4GB it can access as a native 32-bit application.
If anyone has attempted to play on a Giant or Huge Map on a 64-bit system and survived to see the Modern Age, please let me know. It'd make my game more enjoyable knowing I stand a chance to see it through...
I have successfully made it to modern era on my XP machine with 3GB switch and medium graphics setting. After the MAF in the industrial era I deleted the cache before loading the game. I did not another MAF until the modern era. I think some of the problem is occurring because obsolete graphics are being stored in the cache and then swaped into graphics memory even though they aren't needed. I could be wrong and more tollerant of the occasional MAF.