by the end of the game (2000ad) you don't need your science rate cranking at 80% or so because the is not much left to research. Having to drop it down to 20% to pay for inflation sholdn't be that devastating at that point.
No one has mentioned settler first. It may take 25 turns to get him out, but a worker takes 15 turns anyway. Having a second city producing and growing as soon as possible is big. You can then be producing a worker and a warrior at the same time. I haven't actually worked out the numbers but...
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