Define "reload"
If you mean "start a game, play some turns, save the game, exit civ, do something else, come back, start civ, reload saved game, continue playing", then yes
If however you mean "start a game, play some turns, save the game, play some more turns, don't like the outcome, reload the save, try a different strategy", with the aim to detect players "cheating", then, short answer, no.
A player can always rehash the second sequence as "start a game, play some turns, save the game, play some more turns, don't like the outcome, exit civ, start civ, reload the save, try a different strategy" which is indistinguishable from the first sequence.