- Mexico starts at war with Maya in 1650 (Hastening their decline)
- Renamed La Plata to Peru, removed the city of La Plata entirely, and added two more Peruvian cities.
- Renamed Colony Adjectives to better reflect their respective cultures.
- Added three new mainland cities for Arawak in South America
- Peru now starts in Lima in 1500, though getting to Europe may be difficult as a result
- Removed the Maya, Inca, and Muisca from the 1750 start
- Some other minor city changes