Honestly despite certain affinity association no improvement is really affinity specific, if you don;t go into that top left part of the tree for either super gens or super farms you are not competitive, period.
*cough* academy spam *cough*
Made for Supremacy. Go wide, 3-5 virtues into Industry, then Knowledge for academy boost and reduced penalties per city. All those +10% science buildings make academies even better and on top of that you get 3 additional spies and a free virtue on your natural tech path (everything @ tier2).
Early game is a bit slower, you need quests to boost affinity and health will be an issue constantly but on turn 150, science per turn is just ridiculous compared to other strategies, even with negative health.
On topic: EP is a great wonder but in my opinion, it's not worth it as Harmony/Supremacy.