If i get the question correct. (Warning bad EN)
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Vell. I several tymes pick.
Custom game, fast start, age+1 or +2,
hig dif and no research trade.
Raiding barbarians and agresive AI.
No space race, and time victory.
Slover game.
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Or once (Looooong ago) i pick flat game,
fast start, pick Indians (probably, xp boost to archers units)
Probably lov dificulty
set all AI players in permanent war against me
They give me hell when they continuesly atack my capital and then i laf when i have super elites arches (units xp level: 8,10+? dint remember)
The game was good chalenge and i have fun when i survive another turn

and learn loot about defende. Butt when i finaly start claim to archive irreversible victory they win by religion victory.

But i continue play and erase all cities they left from map.
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Try play on pangea or try islands and build unstopable Naval Empire.
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And? Whats you favorite seting?
PS: I play (C 1,2,3,4,BTS, and HR)